High Fever Plus Mitochondrial Disease and Autism
Autistic spectrum disorders encompass etiologically heterogeneous persons, with many genetic causes. A subgroup of these individuals has mitochondrial disease. Because a variety of metabolic disorders, including mitochondrial disease show regression with fever, a retrospective chart review was performed and identified 28 patients who met diagnostic criteria for autistic spectrum disorders and mitochondrial disease. Autistic regression occurred in 60.7% (17 of 28), a statistically significant increase over the general autistic spectrum disorder population (P < .0001). Of the 17 individuals with autistic regression, 70.6% (12 of 17) regressed with fever and 29.4% (5 of 17) regressed without identifiable linkage to fever or vaccinations. None showed regression with vaccination unless a febrile response was present. Although the study is small, a subgroup of patients with mitochondrial disease may be at risk of autistic regression with fever.
High Fever IS a Side-Effect of MMR Vaccine
Systemic reactions includes fever >103º/39.4 ºC occurs in about 5 to 15% of vaccine recipients between the 7th to 12th day after vaccination and lasts approximately 1 to 2 days. In some cases, the fever may be coincidental, due to other infections.
High Fevers Need Treatment Immediately in Infants & Children
Ten children with median age 5.9 years were enrolled for analysis. Influenza-associated encephalitis/encephalopathy appeared in the spring and summer, with a delayed peak comparing with the occurrence of pneumonia and septic shock. The neurological symptoms developed rapidly within median 1 day after the first fever episode. All patients had consciousness disturbance. Seven patients (70%) had seizures at initial presentation, and six of them had status epilepticus. Anti-viral treatments were applied in all patients, with median door-to-drug time 0.9 h for oseltamivir and 6.0 h for peramivir. Multi-modality treatments also included steroid pulse therapy, immunoglobulin treatment, and target temperature management, with 85.2% of the major treatments administered within 12 h after admission. Nine of the ten patients recovered without neurological sequelae. Only one patient had epilepsy requiring long-term anticonvulsants and concomitant cognitive decline.
Treating Fever with Tepid Water Bath
"To sponge your child, place him in his regular bath (tub or baby bath), but put only 1 to 2 inches of tepid water (85–90 degrees Fahrenheit, or 29.4–32.2 degrees Celsius) in the basin. If you do not have a bath thermometer, test the water with the back of your hand or wrist. It should feel just slightly warm. Do not use cold water, since that will be uncomfortable and may cause shivering, which can raise his temperature. If your child starts to shiver, then the water is too cold. Shivering can make a fever worse; take your child out of the bath if he shivers.Seat your child in the water—it is more comfortable than lying down. Then, using a clean washcloth or sponge, spread a film of water over his trunk, arms, and legs. The water will evaporate and cool the body. Keep the room at about 75 degrees Fahrenheit (23.9 degrees Celsius), and continue sponging him until his temperature has reached an acceptable level. Never put rubbing alcohol in the water; it can be absorbed into the skin or inhaled, which can cause serious problems, such as coma.Usually sponging will bring down the fever by one to two degrees in thirty to forty-five minutes. However, if your child is resisting actively, stop and let him just sit and play in the water. If being in the tub makes him more upset and uncomfortable, it is best to take him out even if his fever is unchanged. " (Link)
Infants, Children and Fever Reducing Drugs
- "No matter how you and your doctor decide to approach treating your child’s fever, keep in mind these other important safety tips:
- Most physicians recommend only treating a fever with medicines if the fever is above 102° F.
- Talk to your doctor before giving a pain reliever or fever reducer containing ibuprofen if your baby is younger than 6 months.
- Talk to your doctor before giving acetaminophen to a child younger than 2 years to obtain the proper dosing instructions.
- Temperature in infants can be most accurately measured using a digital rectal thermometer.
- Before giving your child any medicines, make sure you know your child’s weight. Dosing is based on weight, not age.
- Make sure to read the package label very carefully for proper dosing.
- Acetaminophen is most commonly administered at a dose of 10 mg/kg to 15 mg/kg every four hours, whereas ibuprofen is usually administered at a dose of 10 mg/kg every six hours, so the pattern of alternating these two medicines may not be apparent to some.
- Always use the measuring device that comes with the medicine. Do not mix and match dosing devices.
- Don’t give aspirin to anyone under 12 years of age unless instructed by your doctor.
- Call your doctor if your child’s fever is not responding to treatment or lasts longer than one day." (Link)